Department of Chemistry - The Scripps Research Institute, Jupiter, Florida
Thursday, March 30, 2016
4:10 p.m. - 1414 Molecular Biology Building
Host: Walter Moss
"Sequence-based design of small molecules targeting RNA"
A challenge in biomedical research is to rapidly convert genome sequence into lead drugs. The Disney group has developed methods that can quickly and accurately convert genome sequence, namely the RNA products of the genome, into lead therapeutic targets. The general approach described herein is very different from typical drug discovery efforts that often rely on screening of a single drug target to identify lead compounds. It is an attempt to advance a rational, predictable approach to drug disease-causing RNAs with small molecules. In this talk, we will describe various aspects of this technology. This includes the development of rapid screening assays to assess and score the binding of small molecules to RNA folds. By using this information and RNA secondary structure prediction, a target agnostic approach (termed Inforna) is used to selectively drug an oncogenic RNA from sequence, providing in vivo modulators of oncogenic microRNAs. In addition, we present approaches to allow for a disease affected cell to make its own drug on-site.
BBMB GRADUATE STUDENTS ARE REQUIRED TO ATTEND!
PLEASE JOIN US AT 3:45 P.M. IN THE MBB ATRIUM FOR REFRESHMENTS