Daniel Billadeau Seminar

Mayo Clinic Immunology

Thursday, March 9, 2017
4:10 p.m. - 1414 Molecular Biology Building
Host: Stone Chen

"Endosomal Receptor Trafficking: a WASH with Complexes"

Plasma membrane constituents such as lipids and proteins are actively internalized and recycled back to the plasma membrane via the endosomal system in order to maintain tissue and cellular homeostasis. It has been known for some time that F-actin was generated on endosomes, but the protein(s) that directed this F-actin accumulation as well as the impact of F-actin on endosome dynamics and receptor trafficking was unclear. Our discovery of the Wiskott-Aldrich Syndrome homologue, WASH, as the primary regulator of Arp2/3-generated branched F-actin on endosomes has revealed important insights into endosomal biology and disease.

BBMB GRADUATE STUDENTS ARE REQUIRED TO ATTEND!
PLEASE JOIN US AT 3:45 P.M. IN THE MBB ATRIUM FOR REFRESHMENTS